This report describes the rationale, approaches, organization, and resource development leading to a large-scale deletion bin map of the hexaploid wheat genome. Accompanying reports in this issue detail results from chromosome bin-mapping of expressed sequence tags representing genes onto the seven homoeologous chromosome groups and a global analysis of the entire mapped wheat EST data set. Among the resources developed were the first extensive public wheat EST collection. Described are protocols for sequencing, sequence processing, EST nomenclature, and the assembly of (...) ESTs into contigs. These contigs plus singletons were used for selection of distinct sequence motif unigenes. Selected ESTs were rearrayed, validated by 5′ and 3′ sequencing, and amplified for probing a series of wheat aneuploid and deletion stocks. Images and data for all Southern hybridizations were deposited in databases and were used by the coordinators for each of the seven homoeologous chromosome groups to validate the mapping results. Results from this project have established the foundation for future developments in wheat genomics. (shrink)

What I call the Doxastic Puzzle, is the impression that while each of these claims seems true, at least one of them must be false: (a) Claims of the form ‘S ought to have doxastic attitude D towards p at t’ are sometimes true at t, (b) If Φ-ing at t is not within S’s effective control at t, then it is false, at t, that ‘S ought to Φ at t’, (c) For all S, p, and t, having doxastic (...) attitude D towards p at t is not within S’s effective control at t. All three natural replies to the puzzle have been pursued. Some have claimed that doxastic attitudes like believing that p are, in fact, within our effective control, or sufficiently so. Others have claimed that doxastic ought-claims, strictly speaking, are always false. And some have denied that effective control is required for the adequacy of doxastic ought-claims in general. I here pursue and examine a different strategy. In the first part of this paper, I argue that these claims are not only each true but actually not in tension with each other in the first place. Instead of attempting to dispel the puzzle, this solution proposes to evade it instead: to solve it by properly understanding, and by thereby accepting without contradiction, all of its constitutive claims. In the second part of the paper, I argue that the evasive strategy forces us to re-think our understanding of the place of normative reasons in epistemology. More exactly, it seems to come at the cost of one central way of thinking about our reasons for having doxastic attitudes, one where such reasons are good-standing exemplars of normative reasons in general. The evasive strategy, that is, threatens to lead us very quickly to a deflationary picture of epistemic normativity: it rescues normative talk, but sacrifices normative substance. I conclude by explaining why I think this is more consequential than some have made it out to be, and by suggesting that these consequences are welcome nonetheless. (shrink)

Skeptical theism, broadly construed, is an attempt to leverage our limited cognitive powers, in some specified sense, against “evidential” and “explanatory” arguments from evil. Since there are different versions of these kinds of arguments, there are correspondingly different versions of skeptical theism. In this paper, I consider four challenges to three central versions of skeptical theism: (a) the problem of generalized skepticism, (b) the problem of moral skepticism, (c) the problem of unqualified modal skepticism, and (d) the challenge from Bayesian (...) epistemology. (shrink)

We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

We prove the following theorem. Let G be a connected simple bad group (i.e. of finite Morley rank, nonsolvable and with all the Borel subgroups nilpotent) of minimal Morley rank. Then the Borel subgroups of G are conjugate to each other, and if B is a Borel subgroup of G, then $G = \bigcup_{g \in G}B^g,N_G(B) = B$ , and G has no involutions.

Initial evaluation structures (IESs) currently proposed as the earliest detectors of affective stimuli (e.g., amygdala, orbitofrontal cortex, or insula) are high-order structures (a) whose response latency cannot account for the first visual cortex emotion-related response (~80 ms), and (b) lack the necessary infrastructure to locally analyze the visual features that define emotional stimuli. Several thalamic structures accomplish both criteria. The lateral geniculate nucleus (LGN), a first-order thalamic nucleus that actively processes visual information, with the complement of the thalamic reticular nucleus (...) (TRN) are proposed as core IESs. This LGN–TRN tandem could be supported by the pulvinar, a second-order thalamic structure, and by other extrathalamic nuclei. The visual thalamus, scarcely explored in affective neurosciences, seems crucial in early emotional evaluation. (shrink)

The Alperin-Goldschmidt Fusion Theorem [1, 5], when combined with pushing up [7], was a useful tool in the classification of the finite simple groups. Similar theorems are needed in the study of simple groups of finite Morley rank, in the even type case (that is, when the Sylow 2-subgroups are of bounded exponent, as in algebraic groups over fields of characteristic 2). In that context a body of results relating to fusion of 2-elements and the structure of 2-local subgroups is (...) needed: pushing up, and the classification of groups with strongly or weakly embedded subgroups, or have strongly closed abelian subgroups (c.f, [2]). Two theorems of Alperin-Goldschmidt type are proved here. Both are needed in applications.The following is an exact analog of the Alperin-Goldschmidt Fusion Theorem for groups of finite Morley rank, in the case of 2-elements:Theorem 1.1.Let G be a group of finite Morley rank, and P a Sylow2-subgroup of G.If A, B⊆P are conjugate in G, then there are subgroups Hi≤Pand elementsxi∈N(Hi)for1 ≤i≤n,and an elementy∈N(P),such that for all i:1.Hiis a tame intersection of two Sylow2-subgroups;2.CP(Hi) ≤Hi;3.N(Hi)/Hiis2-isolatedand(a)(b). (shrink)

This book offers an introduction to the Sophists of fifth-century Athens and a new overall interpretation of their thought. Since Plato first animadverted on their activities, the Sophists have commonly been presented as little better than intellectual mountebanks - a picture which Professor Kerferd forcefully challenges here. Interpreting the evidence with care, he shows them to have been part of an exciting and historically crucial intellectual movement. At the centre of their teaching was a form of relativism, most famously expressed (...) by Protagoras as 'Man is the measure of all things', and which they developed in a wide range of views - on knowledge and argument, virtue, government, society, and the gods. On all these subjects the Sophists did far more than simply provoke Plato to thought. Their contributions were substantial and serious; they inaugurated the debate on many central philosophical questions and decisively shifted the focus of philosophical attention from the cosmos to man. (shrink)

Synthetic biology, as a research field, brings together molecular life scientists, computational biologists, and social scientists to engineer biological systems toward societally desired goals. Given the field’s broad multidisciplinarity and relatively young age, innovative educational methods are required to provide students with the needed background knowledge to push the field forward in the future. The international Genetically Engineered Machine competition is such an example where education and high-level research merge, providing the synthetic biology field with trained students, new ideas, and (...) novel results. In the 2021 edition alone, 343 teams from across the world completed the competition to tackle societal problems with synthetic biology. As Wageningen University & Research celebrates 10 years of participation in iGEM, we share our thoughts and experiences on supervising iGEM teams, which is especially relevant to organizers of current and new teams, and also others interested in the iGEM competition. (shrink)

The present article, more than to deepen in the polemic classic Popper - Kuhn regarding the progress of the science, seeks to indicate some fundamental pillars that should be kept in mind as possibility for the elaboration of a curriculum in the teaching of the sciences. It is rescued of this discus..

El objeto del presente trabajo es examinar las relaciones entre la guerra, la política y la moral, desde la Ilustración europea a nuestra Posmodernidad global. Para ello, seleccionamos dos muestras representativas: una defensa política de la guerra, el realismo político, y una defensa moral de la paz, el antibelicismo popular. Analizamos ambos, subrayando sus principales argumentos y mostrando sus consecuencias históricas. Finalmente, abordamos las nuevas guerras de la segunda mitad del siglo XX y el comienzo de este Milenio.

Partiendo de la descripción y caracterización general del poder en la sociedad occidental contemporánea realizada por M. Foucault, tratamos de responder algunas preguntas relativas a la resistencia y alternativa a la dominación, siguiendo la experiencia y la reflexión de X. Tarrío, un preso común, que, a nuestro modo de ver, muestra el papel que la moral y el derecho pueden �y deben� jugar en las prácticas y procesos de apropiación y apoderamiento y de oposición y contestación a la dominación.

El objeto de este trabajo es estudiar la relación del filósofo francés Roland Barthes (1915-1980) con la religión, en concreto el cristianismo. Para ello, indagaremos la presencia de la religión, como objeto, como tema y como motivo, en las obras de Barthes y en algunos escritos personales suyos. En conclusión, mostraremos que el cristianismo está presente a lo largo de toda su obra y es importante desde el punto de vista de este autor.

The aim of this text is to examine the issue of truth telling in doctor-patient relationships, namely in the case of terminal patients. We analyze the problems and attitudes regarding truth telling that there are present when patients suffer from mortal diseases. We conclude that it is very important to keep a fluent and truthful communication in the doctor-patient relationship. We also examine and stress the role that general practitioners can play in the care of terminal patients at their home (...) and with their friends and/or relatives. (shrink)

In the modular design of generative theory the syntax-semantics interface has accounted all along for meanings at the level of Logical Form. The syntax-pragmatics interface, on the other hand, is the result of what one may call the 'pragmatic turn' in the linguistic theory, where content is partitioned into given and new information. In other words, the structural division of the clause has been subjected to criteria of information, or discourse structure. Both interfaces require a structurally descriptive inventory whose specific (...) shapes can be motivated on theory-internal grounds only. The present collection of original articles develops the concept of these interfaces further. The papers in the first section focus on the syntax-semantics interface, those in the second section on the syntax-pragmatics interface. (shrink)

The Reliquary of the Manger in the Church of São Roque in Lisbon was created in the early seventeenth century to house supposed fragments of the crib in Bethlehem, given to the Jesuits in Lisbon by Pope Clement VIII. The gilded and silvered bronze reliquary was paid for in part by a donation of c. 1615 from Donna Maria Rolim de Moura, wife of Luís da Gama, a great-grandson of Vasco da Gama. The size of the donation—specifically, the (...) coin involved--has been variously reported and this investigation argues for a correct value, as well as presenting its equivalence in modern currency. The argument is backed up by the discovery in Lisbon of an early seventeenth-century inventory which records the donation. (shrink)

All-encompassing text examines every aspect of coma from neurochemistry, monitoring, and treatments to prognostic factors.

In the article "The Epistemological Nature of Information Modeling" [Gnoseologicheskaia priroda informatsionnogo modelirovaniia], Voprosy filosofii, 1963, No. 10, Academician V. M. Glushkov examines two important methodological aspects of the modeling of natural objects and phenomena in the contemporary natural sciences. The first consists of the informational nature of the models created, and the second of their dynamism. The dynamic nature of today's models in the natural sciences means that it is not so much the material structure of the object that (...) is modeled as its behavior and functions in some sphere of natural phenomena. In this sense, the models under examination may also be termed functional, as distinct from the structural models pertaining to a static description of objects. (shrink)

"It is the purpose of this article to attempt to re-examine the account of Thrasymachus' doctrine in Plato's Republic, and to show how it can form a self-consistent whole. [...] In this paper it is maintained that Thrasymachus is holding a form of [natural right]." Note: Volume 40 = new series 9.